Title: Simulation of Dendritic Cav1.3 Channels in Cat Lumbar Motoneurons: Spatial

We used computer simulations to study the dendritic spatial distribution of low voltageactivated L-type calcium (Cav1.3 type) channels, which mediate hysteretic persistent inward current (PIC) in spinal motoneurons. This study was prompted by the growing experimental evidence of the functional interactions between synaptic inputs and active conductances over the motoneuron dendritic tree. A compartmental cable model of an adult cat α-motoneuron was developed in NEURON simulation environment comprising the detailed morphology of type-identified triceps surae α-motoneuron and realistic distribution of group Ia afferent-to-motoneuron contacts. Simulations of different distributions of Cav1.3 channels were conducted, and the resultant behavior was compared to experimental data. Our results suggest that Cav1.3 channels do not uniformly cover the whole motoneuron dendritic tree. Instead, their distribution is similar to that of synaptic contacts. We found that Cav1.3 channels are primarily localized to a wide intermediate band overlapping with the dendritic Ia-synaptic territory at dendritic distances of 300 to 850 μm (0.62 ± 0.21λ) from the soma in triceps surae α-motoneurons. These findings explain the functional interaction between synaptic inputs and the Cav1.3 channels over the motoneuron dendritic tree. S.M. ElBasiouny, D. J. Bennett, and V. K. Mushahwar 2